一、基本信息

毕思学，中药药理学博士，PG电子·游戏PG电子·游戏副教授，硕士生导师，暨南大学博士后，山东药理学会中药药理专业委员会委员。研究方向为天然药物活性成分的分离纯化及其免疫抗肿瘤活性研究，涉及小分子药物、多糖及蛋白类药物的提取分离纯化，中药抗肿瘤药理学及多糖类药物以肿瘤相关巨噬细胞为靶点的免疫抗肿瘤研究。主持国家自然科学基金、山东省自然科学基金、广东省自然科学基金等研究项目，在《Oncogene》等学术期刊发表论文18篇，其中SC以第一作者及通讯作者发表SCI I区文章2篇、II区文章6篇。

二、学术经历

2008/09-2012/06 ：PG电子·游戏药学院，药学专业（本科）

2012/09 -2018/06：暨南大学，药学院，中药药理学专业（双一流学科），硕-博连读（3+3）研究生。

2018/11-2020/11：暨南大学PG电子·游戏在站博士后。

三、主持科学研究项目

四、代表性成果

1Xuehui Cui1 , Yitong Gong1, Jun Ge, Xiaofei Feng, Xuemei Xiong, Zhen Shi, Qiusheng

Zheng* , Defang Li, Sixue Bi.α-Solanine induces ferroptosis in nasopharyngeal carcinoma via targeting HSP90α/p53 axis.Journal of Functional Foods. 2023, 104, 105517.

  1. Sixue Bi#, Weijuan Huang#, Shan Chen, Chunhua Huang, Chunlei Li, Zhongyi Guo, Jianing Yang, Xianjing Hu, Jianhua Zhu, Liyan Song, Rongmin Yu. Cordyceps militaris polysaccharide converts immunosuppressive macrophages into M1-like phenotype and activates T lymphocytes by inhibiting the PD-L1/PD-1 axis between TAMs and T lymphocytes. International Journal of Biological Macromolecules. 2020, 150, 261–280.

 (2区，IF: 5.163)

  1. Sixue Bi#, Yongshuai Jing#, Qinqin Zhou, Xianjing Hu, Jianhua Zhu, Zhongyi Guo, Liyan Song*, Rongmin Yu*. Structural elucidation and immunostimulatory activity of a new polysaccharide from Cordyceps militaris. Food and Function. 2018, 9, 279–293. (1区，IF: 4.171)

  2.  Weijuan Huang#, Xiaopeng Tian#, Sixue Bi#, Sirui Zhang#， Tingsha He et al. The β-catenin/TCF-4-LINC01278-miR-1258-Smad2/3 axis promotes hepatocellular carcinoma metastasis. Oncogene. 2020. Online. (共同一作，IF=7.971，1区）

  3.  Wanying Liu#, Sixue Bi#, Chunlei Li, Hang Zheng, Zhongyi Guo, Yuanyua, Luo, Xiaozheng Ou, Liyan Song, Jianhua Zhu, Rongmin Yu*.Purification and characterization of a new cysteine-rich secretory protein-related isolated from Scapharca broughtonii with its immunomodulatory activity.Marine Drugs.2020, 18, 299. (共同一作，2区, IF=4.072）

  4. Yao Wen#，Sixue Bi#，Xianjing Hu#，Jianing Yang，Chunlei Li，Hang Li，Dong Bo Yu，Jianhua Zhu，Liyan Song，Rongmin Yu. Structural characterization and immunomodulatory mechani**s of two novel glucans from Morchella importuna fruiting bodies. International Journal of Biological Macromolecules. 2021, 183, 145–157. (共同一作, 2区，IF: 6.79)

  5. Hui Shi#,SixueBi#, Hang Li,Jianhuan Li,Chunlei Li,RongminYu, Liyan Song,Jianhua Zhu.Purification and characterization of a novel mixed-linkage α,β-d-glucan from Arca subcrenata and its immunoregulatory activity.  International Journal of Biological Macromolecules. 2021, 182, 207–216. (共同一作, 2区，IF: 6.79)

  6.  Dan Peng, Yao Wen, Sixue Bi, Chunhua Huang, Jianing Yang, Zhongyi Guo, Weijuan Huang, Jianhua Zhu, Rongmin Yu, Liyan Song. A new GlcNAc-containing polysaccharide from Morchella importuna fruiting bodies: Structural characterization and immunomodulatory activities in vitro and in vivo. International Journal of Biological Macromolecules. 2021, 192, 1134–1149.(2区，IF: 6.79)

五、 学术**

山东药理学会中药药理专业委员会委员


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